Michigan Institute for Clinical & Health Research
Celebrating its 10th year, the Michigan Institute for Clinical & Health Research (MICHR) empowers researchers and research communities, within and outside U-M, to create a positive impact on health. The research support provided by MICHR significantly influences the translation of investigative science into innovative improvements in clinical care and health policy.
MICHR is led by George Mashour, M.D., Ph.D., who also serves as the Associate Dean of the Medical School and the newly-appointed Executive Director of Translational Research in the U-M Office of Research. In this latter capacity, he reports directly to the U-M Vice President for Research and oversees translational endeavors across all U-M schools and campuses. MICHR is a strong partner with the Medical School’s Office of Research, including the Fast Forward Clinical Trial Transformation initiative.
In 2014, the Dean, the Medical School Research Board of Directors (RBOD), and MICHR identified the enterprise-wide goal of transforming clinical trials at the University of Michigan by 2018. Dr. Mashour is co-Chair of the Clinical Trials Subcommittee, and MICHR is co-leading many initiatives related to clinical trials. Part of the Strategic Research Initiative, “Fast Forward Clinical Trials” is engaging the entire institution in creating the new knowledge needed to improve clinical care, value, and health outcomes by successfully executing a diverse portfolio of high-quality clinical trials. Strategies to achieve this goal include:
- foster a UMHS culture that values, rewards, and supports clinical trial activities;
- develop a coordinated, sustainable infrastructure that supports operational excellence throughout the life cycle of clinical trials;
- develop a highly trained, innovative, and skilled workforce, including those who initiate and those who conduct clinical trials;
- translate U-M discoveries into clinical trials;
- fully integrate the clinical trials enterprise and the clinical care delivery system;
- and demonstrate the value of clinical trials to patients, families, and society.
The impact of MICHR’s work with researchers has been powerful. The recent success of 3D-printed tracheal splints is a salient example. As Dr. Glenn Green, Professor of Otolaryngology, stated: “Assistance from MICHR was invaluable in negotiating the complex regulatory framework to create life-saving devices for children. Getting these devices to children would have taken years longer, if even possible, without stepwise guidance and early translational support from MICHR. MICHR’s support has literally saved several children that would have otherwise passed away.”
MICHR supports investigators and study teams in all U-M schools and colleges. We encourage investigators to think of MICHR as a unique research resource and extended research team. Visit www.michr.umich.edu for more information, or to make an appointment for consultation.
Enabling and enhancing research
MICHR is a catalytic partner that educates, funds, connects, and supports research teams at NCRC, and beyond. Their many services for investigators and research team members include:
- Consultation & advising: expert opinions on everything from study aims, feasibility, biostatistics, and bioethics to protocols, staffing, budgeting, collaboration, regulatory support, grant proposals, community engagement, and participant recruitment.
- Education & mentoring: competency-based education for clinical trial conduct, based on international good clinical practice standards; training relevant to clinical research through degree, certificate, and mentored research programs; community-based participatory research; informatics tool workshops; and more.
- Funding & grant writing: seed grants, bench-to-bedside pilot grants for Phase 1 and Phase 2/3 studies, and grant review and editing services to strengthen proposals.
- Study preparation: partnership development with community-based organizations and practice-based research networks; protocol development and review, data capture tools, database development, and standard operating procedures; customized participant recruitment strategies and tools, including UMClinicalStudies.org; FDA submission support; and assistance with industry-sponsored study start-ups.
- Study conduct: randomization tools, study/data monitoring/mentoring, biostatistical analysis, and more; clinical research facility with highly-skilled clinical research teams providing extended stay services and outpatient appointments, a mobile clinical research team, and a core research lab for specimen collection, processing, shipping, and storage; and research informatics tools for electronic data capture.
- Results dissemination: support for manuscripts, co-writing with community partners, and a communication toolkit for dissemination to a wide range of audiences.